Desumoylated
WebDescription: Mus musculus dynamin 1-like (Dnm1l), transcript variant 2, mRNA. (from RefSeq NM_001025947) RefSeq Summary (NM_001025947): This gene encodes a member of the dynamin family. The encoded protein is localized to the cytoplasm and mitochondrial membrane, is involved in mitochondrial and peroxisomal division, and is … WebJun 1, 2024 · Data from clinical research and our previous study have suggested the potential involvement of SENP1, the major protease of post-translational SUMOylation, in cardiovascular disorders. Here, we ...
Desumoylated
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WebSENP5 also showed isopeptidase activity and desumoylated SUMO-modified RANGAP1, with highest activity toward SUMO2 and SUMO3. In cotransfection assays, SENP5 preferentially reduced high molecular mass conjugates of SUMO2 compared with SUMO1. Deletion of the noncatalytic N-terminal domain of SENP5 led to loss of nucleolar … WebDescription: Homo sapiens SIN3 transcription regulator family member A (SIN3A), transcript variant 3, mRNA. (from RefSeq NM_001145357) RefSeq Summary (NM_001145357): The protein encoded by this gene is a transcriptional regulatory protein. It contains paired amphipathic helix (PAH) domains, which are important for protein-protein interactions …
WebOct 10, 2024 · The deSUMOylation enzyme, SENP1, has recently been shown to have a prooncogenic role in cancer; however, mechanistic understanding of this is limited. Here … WebJan 1, 2024 · The SENP3 and SUMOylated/deSUMOylated drp1 levels, mitochondrial morphology, mitochondrial membrane potential (MMP) and apoptosis rate were evaluated. In vivo, mice were assigned to a normal, type 2 diabetic or type 2 diabetic SENP3-siRNA mouse groups. Then, blood–retinal barrier function and retinal tissue structure were …
WebJun 30, 2013 · The findings that Pin1 is deSUMOylated and activated by SENP1 suggest an exciting novel mechanism to control Pin1 catalytic activity in human disease. The most notable example is cancer, in which Pin1 and SENP1 have been shown to have many correlated functions in tumorigenesis, although they have not been studied together before. WebDeSUMOylated AMPKα (K118R) exhibited shortened half-life as compared with wild-typed AMPKα (Fig. 6H), which was consistent with the observation that SENP2 repressed …
WebBy examining both LC3-II induction and autophagosome formation with Mito-pHfluorin, we observed that while SENP3 knockdown blocks DFP-induced mitophagy, expression of “constitutively deSUMOylated” FIS1 K149R restores DFP-induced mitophagy in SENP3-lacking cells. Together, these results demonstrate that SENP3 promotes DFP-induced …
WebSUMO is a novel ubiquitin-like protein that can covalently modify a large number of nuclear proteins. SUMO modification has emerged as an important regulatory mechanism for protein function and localization. Sumoylation is a dynamic process that is mediated by activating (E1), conjugating (E2), and … how do you build a rabbit hutchWebDec 6, 2024 · Interestingly, RPC3 and RPC4 are differentially sumoylated in response to heat shock, and RPC4 and RPC5 are desumoylated upon MMS treatment (43, 44). Of note, in these studies the human RNAPI subunit RPA34 appeared desumoylated in response to heat stress and MMS, which we have also found upon starvation and … pho invesco waterWebDec 16, 2024 · Mice with the desumoylated THRA had disruptions in cell cycle G 1 /S transition and this was associated with a reduction in the availability of cyclin D2 and cyclin-dependent kinase 2. Results ... how do you build a relationshipWebDictionary entries. Entries where "deSUMOylate" occurs: desumoylate: see also deSUMOylate desumoylate (English) Verb desumoylate (third-person singular simple present desumoylates, present participle desumoylating, simple past and past participle desumoylated) Alternative form of deSUMOylate. désumoyler: désumoyler (French) … pho ironwoodhow do you build a railroadWebDescription: Homo sapiens RAR related orphan receptor A (RORA), transcript variant 1, mRNA. (from RefSeq NM_134261) RefSeq Summary (NM_134261): The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It can bind as a monomer or as a homodimer to hormone response elements upstream of several … how do you buff out paint scuffs on a carWebNational Center for Biotechnology Information pho invesco water resources etf