Phospho-smad2 ser465/467 /smad3 ser423/425
WebThe O72-670 monoclonal antibody specifically binds to the Smad2 protein phosphorylated at the Ser465/467 sites and the Smad3 protein phosphorylated at the Ser423/425 sites. Smad2 and Smad3 are members of the Smad superfamily with observed molecular weights of 60 kDa and 52 kDa, respectively. WebFeb 6, 2015 · Phosphorylation of Smad2 and Smad3 at Ser465/467 and Ser423/425, respectively and nuclear translocation by TGF-β1 are required for transcriptional activity of Smad2 and/or Smad3. ... intracellular localization of phosphorylated Smad2 and/or Smad3 were examined by immunofluorescence using specific anti-phospho-Smad2 and anti …
Phospho-smad2 ser465/467 /smad3 ser423/425
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WebThe Phospho-SMAD2 (Ser465/467) kit enables the cell-based quantitative detection of SMAD2 phosphorylated on Ser465/467, as a readout of the TGFb pathway. See more All inclusive kit High sensitivity Rapid Low sample consumption Download the protocols Size Cat. number selected : - Quantity Request for quotation Prices may differ between countries. WebAnti-phospho-Smad2 (Ser465/467), clone A5S ZooMAb, Cat. No. ZRB04953, is a recombinant Rabbit Monoclonal Antibody that detects Smad2 phosphorylated on serine 465/467 and has been tested forr use in Immunocytochemistry, Immunohistochemistry (Paraffin), Peptide Inhibition Assay, and Western Blotting.
WebJun 19, 2024 · Smad2/3 activation was analyzed by the phosphorylation level at Ser465/467 in Smad2 and Ser423/425 in Smad3. In addition, Stat3 activation was analyzed by the phosphorylation level at Tyr705. (b ... Web丁香通为您提供锌指蛋白ikaros抗体商品详情介绍：价格：¥1560 - 1960，货号：bs-8172r ，品牌：晶抗，产地：上海，详见丁香通锌指蛋白ikaros抗体商品详情页；
WebOct 31, 1997 · Phosphorylation sites on Smad2 were localized to a carboxyl-terminal fragment containing three serine residues at positions 464, 465, and 467. In this report, … http://www.asbio.com.cn/shop/category/102-392/page/5
WebJan 11, 2024 · The SMURF2Thr249phosphorylation level was low in human glioblastoma pathology specimens. Introduction of the SMURF2T249Amutant resulted in increased stemness and tumorigenicity of GSCs, recapitulating the SMURF2silencing. Moreover, the inactivation of SMURF2Thr249phosphorylation increases TGF-β receptor (TGFBR) protein …
WebFollowing stimulation by TGF-β, Smad2 and Smad3 become phosphorylated at their carboxyl termini (Ser465 and 467 on Smad2; Ser423 and 425 on Smad3) by TGF-β Receptor I. … how many hours are in 14 yearsWebMar 23, 2024 · Our findings demonstrated the pro-metastatic function of ATAD2 and uncovered the new molecular mechanism by regulating C/EBPβ/TGF-β1/Smad3/Snail signaling pathway, thus providing a potential target … how many hours are in 14 weeksWebSmad3 细胞信号转导分子SMAD3抗体 0.1ml Phospho-Smad3(Ser423/425) 磷酸化细胞信号转导分子SMAD3抗体 0.1ml Phospho-Smad3(Ser425) 磷酸化细胞信号转导分子SMAD3抗体 0.1ml Phospho-Smad3(Ser208) 磷酸化细胞信号转导分子SMAD3抗体 0.1ml SMC1 染色体结构维持蛋白1抗体 0.2ml 人抗血小板抗体IgG(PA ... how a hv transformer worksWeb9251S Phospho-SAPK/JNK (Thr183/Tyr185) Antibody 200 ul 3101S Phospho-Smad2 (Ser465/467) Antibody. 100 ul 9520S Phospho-Smad3 (Ser423/425) (C25A9) Rabbit mAb … how a husband weaned his wife from fairytalesWebLysates were blotted using Purified Mouse Anti-Smad2 (pS465/pS467)/Smad3 (pS423/pS425) antibody (Clone O72-670; 2 µg/mL). Phosphorylated Smad2 and Smad3 were identified as ~60 kDa and ~52 kDa bands, respectively. The lower molecular weight band detected in mouse spleen lysates is endogenous mouse Ig light chain. how a hvac worksWebJan 1, 2024 · The dynamics of the Smad2/3 phosphorylation provide the key mechanism for regulating the TGF-β signaling pathway, but the details surrounding this phosphorylation remain unclear. Here, using via modulation of Smad2/3 phosphorylation in the linker region. how a husband is to treat his wife bibleWebJan 11, 2024 · The phosphorylation of SMURF2 Thr249 activates its ubiquitin E3 ligase ability to accelerate the proteasomal degradation of SMAD proteins (SMAD1, SMAD2, and SMAD3) in MSCs to control the stemness ... how a hvac thermostat works